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气体信号分子与生物自由基检测仪(TBR4100)
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气体信号分子与生物自由基检测仪(TBR4100)

仪器概况

气体信号分子和生物自由基检测仪,采用电化学检测原理,可以对多种分子的氧化还原产物进行实时检测,从而得知该分子的含量。气体信号分子和生物自由基检测仪,对所检测分子包括NO、CO、HPO、HS等具有高灵敏度和超低噪音的特点。由于NO、H2S和HPO具有独特的100微米及以下的组织电极,因此也可以对动物和植物体内的上述分子进行实时在体的检测。四通道气体信号分子和生物自由基检测仪可以对一个样本中四个不同成分同时进行检测,也可以对四个不同的样本同时进行检测,只需要连接电极到前面板的插口,选择电流范围即可。此外,系统还提供了独立的实时温度检测。



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仪器概况

气体信号分子和生物自由基检测仪,采用电化学检测原理,可以对多种分子的氧化还原产物进行实时检测,从而得知该分子的含量。气体信号分子和生物自由基检测仪,对所检测分子包括NO、CO、HPO、HS等具有高灵敏度和超低噪音的特点。由于NO、H2S和HPO具有独特的100微米及以下的组织电极,因此也可以对动物和植物体内的上述分子进行实时在体的检测。四通道气体信号分子和生物自由基检测仪可以对一个样本中四个不同成分同时进行检测,也可以对四个不同的样本同时进行检测,只需要连接电极到前面板的插口,选择电流范围即可。此外,系统还提供了独立的实时温度检测。




产品名称:  气体信号分子和自由基检测仪
 
工作原理:
 溶液电极或组织电极插入到、溶液或组织中, 上述分子透过专利的生物半透膜进入内电极并在内电极表面产生 氧化还原电流, 输入到电化学工作站并连接到模数转换器, 后者将模拟信号转变为数字信号, 通过电脑软件记录电流并转化为测量分子的含量。
规格型号:
 TBR4100
 
产品特点:

TBR4100 是当今全球唯一一款可以用于动物或植物在体实时检测的设备,可对当前研究热门的气体信号分子(如NO、H2S)和自由基(如HPO)进行实时在体检测,还可以检测动植物体内Glucose的变化情况,以及CO和O2在溶液中的含量
  • 检测范围大:NO的检测范围:0.3nM-100μM      H2S的检测范围:5nM-100μM          CO的检测范围:10nM-10μM             HPO的检测范围:10nM-100mM              Glucose的检测范围:2-25mM/L    O2的检测范围:0.1-100%;
  • 灵敏度高:   NO的检测灵敏度:1-10pA/nM       H2S的检测灵敏度:0.5-2pA/nM      CO的检测灵敏度:0.5pA/nM             HPO的检测灵敏度:0.02-4pA/nM             O2的检测灵敏度:0.3-0.6nA/%;
  • 空间分辨率高:H2S、NO和HPO均具有100µm及以下电极,用于组织内分子检测时空间分辨率极高
  • 快速反应时间:N0:<5s; H2S:<5 s; HP0:<5 s; 02:<10 s; C0:<10 s
  • 一机多用,可以同时检测NO、H2S、HPO、co、Glucose和02
  • 操作简单,标定方便,用户友好的软件操作系统
  • 具有单通道和四通道可选
  • 不同类型(L型、H型和Z型)电极可选,可以应用于不同的研究场合



四通道高效能检测设备;

可检测NO、H2S、HPO、CO、O2和葡萄糖等多个指标;

检测最低限至0.1纳摩尔,灵敏度高;

无论是动物还是植物研究,多个指标均可实时在体检测;

 
应用领域
 TBR4100是心血管生理、病理和药理研究的最佳工具实时在体检测组织内一氧化氮(NO),硫化氢(H2S),过氧化氢(HPO),葡萄糖(Glucose)等4个指标变化;检测溶液中一氧化碳(CO)和氧气(O2)变化。

 针对动物研究


  • 用于缺血再灌注(包括心肌缺血再灌注、 脑缺血再灌注和肾缺血再灌注等)药物保护作用的研究
  • 用于高血压及心血管疾病研究中血管内皮功能紊乱(ROS及氧化应激)及血管用于高血压及心血管疾病研究中血管内皮功能紊乱(ROS及氧化应激)及血管内皮切应力变化引起的血管功能紊乱研究
  • 用于氧化应激与疾病的关系研究以及抗氧化应激,药物的机制研究和筛选
  • 用于糖尿病实验动物模型建立的辅助研究,微血管病变以及药物治疗作用机制探究和筛选
  • 用于脑卒中药物筛选和治疗研究
  • 用于小动物线粒体呼吸和氧化研究中的02消耗, NO 、 H2S和HPO产生的研究
  • 用于微生物代谢研究
  • 自由基与动物疾病关系(老年病
  • 用于各种炎症过程中自由基和ROS指标的研究
  • 用于各种神经信号通路中分子机制的研究

 针对植物研究



  • 用于植物氧应激、盐应激、低温应激和光合作用研究
  • 实时在体检测植物内分子变化
  • 用于植物的信号分子如NO、CO和H2S的研究
  • 用于植物浸渍胁迫、干旱胁迫、低温胁迫和缺磷胁迫的研究

 
参考文献:
 应用于心肌缺血再灌注研究
[ 1] Apocynin Exe血Dose心叩endent Cardioprotective Effi四ts by Attenuating Reactive Oxygen Species in Ischemia/Reperfusion[J]. Qian Chen et al., CardiovascPharm Open Access, 2016, 5(2), 1000176.
[2]  Delivery of Hydrogen Sulfde by Ultrasound Targeted Micro bubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury[J]. Gangbin Chen et al., Scientific Reports, 2016, 6, 30643-30656.
[3] Effects of Mitochondrial-Targeted Antioxidants on Real-Time Blood Nitric Oxide and Hydrogen Peroxide Release in Acute Hyperglycemic Rats[J].
Matthew L. Bertolet et al., Proceedings of the 24也American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Edito时,American Peptide Society, 2015.
[4] Lipopolysaccharide-induced cross-tolerance against renal ischemia一reperfusion injujrγ is mediated by hypoxia- ducibl e factor-2a-regulated nitric oxide production[J]. Kang He et al., Kidney International, 2014, 85, 276-288.
[5] Gp91ds-tat, a selective NADPH oxidase peptide inhibitor, increase咀 blood nitric oxide bioavailability in hind limb ischemia and reperfusion (667.7)[J] Walker S, et al.,Faseb Journal, 2014, 28.

 应用于线植体研究

[ 1] Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics[J].Katalin M6dis et al.,The FASEB Journal, 2013, 27(2), 601-611.
[2] Respiration-dependent Hp2 Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System[J]. Derek A. Drechsel et al., The Journal of Biological Chemis位y, 2010, 285, 27850-27858.
[3]Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing[J].KennethR Olson et al., AmericanJomnal of Physiology-Regulatory,Integrative and Comparative Physiology,2013, 305(6),R592-R603.
[4] Low intensity light stimulates nitrite-dependent nitric oxide synthesis but not oxygen consumption by cytochrome c oxidase: Implications forphototherapy[J].
Kerri A. Ball et al., Journal of Photochemistry and Photobiology B: Biology, 2011, 102(3),182-191.
[5] Nitric oxide scavenging modulates mitochondrial dysfunction induced by hypoxia/reoxygenation[J]. Emmanuel Robin et al., Pharmacological Reports, 2011, 63, 1189-1194.
[6] Nitrite reduction and superoxide-dependent nitric oxide degradation by Arabidopsis mitochondria: Influence of external NAD(P)H dehydrogenases and alternative oxidase in the control of nitric oxide levels[JJ
Alfredo Wulff et al., Nitric Oxide, 2009, 21, 132-139.

 应用于植物学研究
[l] Exogenous nitric oxide improves sugarcane growth and photosynthesis under water deficit[J] Neidiquele M. Silveira et 址,Planta, 2016, 244, 181-190.
[2] Enhanced chloroplastic generation of Hp2 in stress-resistant Thellungiella salsuginea in comparison to Arabidopsis仕1aliana[耳Monika Wiciarz et al.,Physiologia plantarum, 2015, 153.3, 467-476.
[3] Calcium-sensing receptor regulates stomatal closure through hydrogen peroxide and nitric oxide in response to extracellular calcium in Arabidopsis[J].
Wen-Hua Wang et al., Journal of Experimental Botany, 2012, 63(1), 177-190.
[4]Specificity of Polyamine Effects on NaCl-induced Ion Flux Kinetics and Salt Stress Amelioration in Plants[J]. Camilla Pandolfi et al., Plant Cell Physiol., 2010, 51(3),422-434.

 其他参考文献

[ 1] Elevated Inducible Nitric Oxide Levels and Decreased Hydrogen Sulfide Levels Can Predict the Risk of Coronary Artery Ectasia in Kawasaki Disease[J].Ruixia Song, et al., Pediatr Cardiol, 2016, 37, 322-329.
[2] Hydrogen Sulfide Inhibits High-Salt Diet-Induced Renal Oxidative Stress and Kidney Injurγin Dahl Rats[J]. Pan Huang et 址,Oxidative Medicine and Cellular Longevity, 2016, 2016.
[3] Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles[J].Thuy-Khnh1 Nguyen et al., Chemical Science, 2016, 7, 1016-1027.
[4] The design ofredox active thiol peroxidase mimics: Dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action[J].B. Zadehvakili et al., Biochemical Pharmacology, 2016, 104, 19-28.
[5] Moraxella catarrhalis-produced nitric oxide has dual roles in pathogenicity and clearance of infection in bacterial-host cell cocultures[J].Brian Mocca 巳t al., Nitric Oxide, 2015, 51, 52-62.
[6] Angiopreventive versus angiopromoting effects of allopurinol in the murine sponge model[J].L. A.A. Orellano, et al., Microvascular Research, 2015, 101, 118-126.
[7] Hydrogen-sulfide-mediated vasodilatory effect of nucleoside5 '-monophosphorothioates in perivascular adipose tissue 1 [J]. Jerzy Beltowski et al., Can. J. Physiol. Pha口nacol, 2015, 93, 585-595.
[8] Down-regulated CBS/H2S pathway is involved in high-saIt-induced hypertension in Dahl rats[J].Pan Huang et al., Nitric Oxide, 2015, 46, 192-203.
[9] Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: Critical protective actions of ascorbate and thiocyanate[J].Martin D. Rees et al., Free Radical Biology and Medicine, 2014, 72, 91-103.
[10] Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe? [J].Pooja Naik et al., BMC Neuroscience, 2014, 15, 51-65.
[11] Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway[J]. Bruna P. V. Dantas et al. Molecules, 2014,凹,9773-9785.
[12] L-Theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation[J] Jamila H. Siamwala et al., The Journal ofNutritional Biochemistry, 2013, 24(3),595-605.
[13] Nitric oxide-releasing nanopaηicles accelerate wound healing in NOD-SCIO mice[J].Karin Blecher et al,Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8(8), 1364-1371.
[14] Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint[J].Bridget Fox et al., J. Cell. Mol. Med,2012, 16(4), 896-910.
[15] Pulmonary hypertension in adult Alkl heterozygous mice due to oxidative stress[J].Mirjana Jerkic et al., Cardiovascular Research, 2011, 1-22.
[16] Nitric Oxide Protects Bacteria from Aminoglycosides by Blocking the Energy-Dependent Phases of Drug Uptake[J]. Bruce D. Mccollister et al., Agents Chemother., 2011, 55(日,2189-2196.
[ 17] DosS Responds to a Reduced Electron Transport System To Induce the Mycobacterium tuberculosis DosR Regulon[J]. Ryan W. Honaker et al., J. Bacteriol, 2010, 192(24), 6447-6455.
[18]The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages[J].Matthew Whiteman et al., Antioxidants & Redox Signaling, 2010, 12(10), 1147-1154.
[19] Hydrogen peroxide is the major oxidant product ofxanthine oxidase[J] Eric E. Kelley et al., Free Radical Biology and Medicine, 2010, 48(4), 493-498

   人体内自由基的研究进展中华流行病学杂志
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