气体信号分子与生物自由基检测仪（TBR4100）

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气体信号分子与生物自由基检测仪（TBR4100）

仪器概况

气体信号分子和生物自由基检测仪，采用电化学检测原理，可以对多种分子的氧化还原产物进行实时检测，从而得知该分子的含量。气体信号分子和生物自由基检测仪，对所检测分子包括NO、CO、HPO、H２S等具有高灵敏度和超低噪音的特点。由于NO、Ｈ２Ｓ和HPO具有独特的１００微米及以下的组织电极，因此也可以对动物和植物体内的上述分子进行实时在体的检测。四通道气体信号分子和生物自由基检测仪可以对一个样本中四个不同成分同时进行检测，也可以对四个不同的样本同时进行检测，只需要连接电极到前面板的插口，选择电流范围即可。此外，系统还提供了独立的实时温度检测。

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商品描述

仪器概况

产品名称：	气体信号分子和自由基检测仪

工作原理：
溶液电极或组织电极插入到、溶液或组织中，上述分子透过专利的生物半透膜进入内电极并在内电极表面产生氧化还原电流，输入到电化学工作站并连接到模数转换器，后者将模拟信号转变为数字信号，通过电脑软件记录电流并转化为测量分子的含量。
规格型号：
TBR4100

产品特点：
TBR4100 是当今全球唯一一款可以用于动物或植物在体实时检测的设备，可对当前研究热门的气体信号分子（如NO、H2S）和自由基（如HPO）进行实时在体检测，还可以检测动植物体内Glucose的变化情况，以及CO和O2在溶液中的含量检测范围大：NO的检测范围：0.3nM-100μM H2S的检测范围：5nM-100μM CO的检测范围：10nM-10μM HPO的检测范围：10nM-100mM Glucose的检测范围：2-25mM/L O2的检测范围：0.1-100%；灵敏度高： NO的检测灵敏度：1-10pA/nM H2S的检测灵敏度：0.5-2pA/nM CO的检测灵敏度：0.5pA/nM HPO的检测灵敏度：0.02-4pA/nM O2的检测灵敏度：0.3-0.6nA/%；空间分辨率高：H2S、NO和HPO均具有100µm及以下电极，用于组织内分子检测时空间分辨率极高快速反应时间：N0:<5s; H2S:<5 s; HP0:<5 s; 02:<10 s; C0:<10 s 一机多用，可以同时检测NO、H2S、HPO、co、Glucose和02 操作简单，标定方便，用户友好的软件操作系统具有单通道和四通道可选不同类型（L型、H型和Z型）电极可选，可以应用于不同的研究场合四通道高效能检测设备；可检测NO、H2S、HPO、CO、O2和葡萄糖等多个指标；检测最低限至0.1纳摩尔，灵敏度高；无论是动物还是植物研究，多个指标均可实时在体检测；

应用领域：
TBR4100是心血管生理、病理和药理研究的最佳工具。实时在体检测组织内一氧化氮（NO），硫化氢（H2S），过氧化氢（HPO），葡萄糖（Glucose）等4个指标变化；检测溶液中一氧化碳（CO）和氧气（O2）变化。针对动物研究用于缺血再灌注（包括心肌缺血再灌注、脑缺血再灌注和肾缺血再灌注等）药物保护作用的研究用于高血压及心血管疾病研究中血管内皮功能紊乱（ROS及氧化应激）及血管用于高血压及心血管疾病研究中血管内皮功能紊乱（ROS及氧化应激）及血管内皮切应力变化引起的血管功能紊乱研究用于氧化应激与疾病的关系研究以及抗氧化应激，药物的机制研究和筛选用于糖尿病实验动物模型建立的辅助研究，微血管病变以及药物治疗作用机制探究和筛选用于脑卒中药物筛选和治疗研究用于小动物线粒体呼吸和氧化研究中的02消耗， NO 、 H2S和HPO产生的研究用于微生物代谢研究自由基与动物疾病关系（老年病）用于各种炎症过程中自由基和ROS指标的研究用于各种神经信号通路中分子机制的研究针对植物研究用于植物氧应激、盐应激、低温应激和光合作用研究实时在体检测植物内分子变化用于植物的信号分子如NO、CO和H2S的研究用于植物浸渍胁迫、干旱胁迫、低温胁迫和缺磷胁迫的研究

参考文献：
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[13] Nitric oxide-releasing nanopaηicles accelerate wound healing in NOD-SCIO mice[J].Karin Blecher et al，Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8(8), 1364-1371. [14] Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint[J].Bridget Fox et al., J. Cell. Mol. Med，2012, 16(4), 896-910. [15] Pulmonary hypertension in adult Alkl heterozygous mice due to oxidative stress[J].Mirjana Jerkic et al., Cardiovascular Research, 2011, 1-22. [16] Nitric Oxide Protects Bacteria from Aminoglycosides by Blocking the Energy-Dependent Phases of Drug Uptake[J]. Bruce D. Mccollister et al., Agents Chemother., 2011, 55（日，2189-2196. [ 17] DosS Responds to a Reduced Electron Transport System To Induce the Mycobacterium tuberculosis DosR Regulon[J]. Ryan W. Honaker et al., J. Bacteriol, 2010, 192(24), 6447-6455. [18］The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages[J].Matthew Whiteman et al., Antioxidants & Redox Signaling, 2010, 12(10), 1147-1154. [19] Hydrogen peroxide is the major oxidant product ofxanthine oxidase[J] Eric E. Kelley et al., Free Radical Biology and Medicine, 2010, 48(4), 493-498 人体内自由基的研究进展（中华流行病学杂志）